STUDYING TOXICITY OF INHALED GENERAL ANAESTHETICS
نویسندگان
چکیده
منابع مشابه
Climate effect of inhaled anaesthetics.
Almost all areas of human activity have the potential to influence climate. The administration of inhalation anaesthetics is one such activity. However, since the first dedicated study in 1989 of the possible role of halogenated anaesthetics, they have received only sporadic interest. Two recent papers, published in this issue of the British Journal of Anaesthesia and in Anesthesia and Analgesi...
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In summary, anaesthetics and drugs used perioperatively are all xenobiotics and can be metabolized mainly by microsomal enzyme systems, which have a high activity in the liver. These enzyme systems are induced by repeated pre-administration of drugs, such as barbiturates and others which are used during the preoperative period. However, according to some reports, aerobic and anaerobic metabolis...
متن کاملSodium channels and the synaptic mechanisms of inhaled anaesthetics.
General anaesthetics act in an agent-specific manner on synaptic transmission in the central nervous system by enhancing inhibitory transmission and reducing excitatory transmission. The synaptic mechanisms of general anaesthetics involve both presynaptic effects on transmitter release and postsynaptic effects on receptor function. The halogenated volatile anaesthetics inhibit neuronal voltage-...
متن کاملSeparation of cough and reflex bronchoconstriction by inhaled local anaesthetics.
Cough and airway constriction are common features of respiratory diseases. Both can be caused by stimulation of airway nerves. We have studied the effects of airway anaesthesia on these reflexes, stimulated by inhaled capsaicin, in order to determine whether they are controlled by the same sensory nerves. Ten volunteers had capsaicin cough dose responses performed before and at 10 min after inh...
متن کاملMeasurement and reduction of occupational exposure to inhaled anaesthetics.
The occupational exposure of hospital staff to inhaled anaesthetics was investigated using a personal sampling device that provides a measure of the average concentrations breathed by a person over a period of time, as distinct from the spot sampling in the general environment. The anaesthetist's average exposure to nitrous oxide and halothane during complete operating sessions was twice that e...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1981
ISSN: 0007-0912
DOI: 10.1016/s0007-0912(19)30532-x